Galectin-1 ameliorates perioperative neurocognitive disorders in aged mice

CONCLUSION: Our findings provide evidence that galectin-1 may inhibit IRAK1 expression, thus suppressing inflammatory response, inhibiting neuroinflammation, and improving ensuing cognitive dysfunction. Collectively, these findings unveil that galectin-1 may elicit protective effects on surgery-induced neuroinflammation and neurocognitive disorders.PMID:33942523 | DOI:10.1111/cns.13645

Source: CNS Neuroscience and Therapeutics - May 4, 2021 Category: Neuroscience Authors: Zhiwen Shen Hui Xu Wen Song Chuwen Hu Mingyan Guo Jinfeng Li Junhua Li Source Type: research