GSE173838 DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner

Contributors : Tyler R Fortuna ; Udai B Pandey ; Dhivyaa RajasundaramSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterMutations in the RNA binding protein, Fused in Sarcoma (FUS), lead to amyotrophic lateral sclerosis (ALS), the most frequent form of motor neuron disease. Cytoplasmic aggregation and defective DNA repair machinery are etiologically linked to mutant FUS-associated ALS. Although FUS is involved in numerous aspects of RNA processing, little is understood about the pathophysiological mechanisms of mutant FUS. Here, we employed RNA-sequencing technology in Drosophila brains expressing FUS to identify significantly altered genes and pathways involved in FUS-mediated neurodegeneration.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research