Even fractures in arm, wrist increase risk for future breaks in postmenopausal women

Current guidelines for managing osteoporosis specifically call out hip or spine fractures for increasing the risk for subsequent bone breaks. But anew UCLA-led study suggests that fractures in the arm, wrist, leg and other parts of the body should also set off alarm bells.A fracture, no matter the location, indicates a general tendency to break a bone in the future at a different location, said Dr. Carolyn Crandall, the study ’s lead author and a professor of medicine at theDavid Geffen School of Medicine at UCLA.“Current clinical guidelines have only been emphasizing hip and spine fractures, but our findings challenge that viewpoint,” Crandall said. “By not paying attention to which types of fractures increase the risk of future fractures, we are missing the opportunity to identify people at increased risk of future fracture and counsel them regarding risk reduction.“Postmenopausal women and their physicians may not have been aware that even a knee fracture, for example, is associated with increased risk of future fractures at other locations of the body.”The study is published today  in the peer-reviewed journal EClinicalMedicine.The researchers examined records from 1993 through 2018 for more than 157,000 women aged 50 through 79. Data was sourced from the Women ’s Health Initiative, a national study funded by the National Heart, Lung, and Blood Institute.The researchers found that among postmenopausal women, initial fractures...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

Related Links:

Stem cells maintain tissue by providing a supply of daughter somatic cells to replace losses. This stem cell activity declines with age, and a sizable fraction of that decline in the most studied populations appears to be a reaction to the aged signaling environment rather than intrinsic dysfunction, at least in earlier old age. The behavior of cells lacking damage is controlled by their epigenetic state, alterations to the genomic machinery that governs the production of specific proteins. Could long term health be significantly improved by altering the epigenetic state of old stem cells, overriding their reaction to the ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
CONCLUSIONS: Osteoporosis is common in prostate cancer patients undergoing androgen deprivation therapy; furthermore, its incidence increases depending on the duration of androgen deprivation therapy. Bone mineral density testing should be considered for all patients on androgen deprivation therapy, especially for those with a lower body mass index and higher serum alkaline phosphatase value.PMID:34542155 | DOI:10.1093/jjco/hyab147
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractBackgroundPrior studies using aggregated data suggest that better care coordination is associated with higher performance on measures of clinical care process; it is unclear whether this relationship reflects care coordination activities of health plans or physician practices.ObjectiveEstimate within-plan relationships between beneficiary-reported care coordination measures and HEDIS measures of clinical process for the same individuals.DesignMixed-effect regression models in cross-sectional data.Participants2013 Medicare Advantage CAHPS respondents (n=152,069) with care coordination items linked to independently c...
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Exp Cell Res. 2021 Sep 16:112834. doi: 10.1016/j.yexcr.2021.112834. Online ahead of print.ABSTRACTAberrant activity of bone resorbing osteoclasts plays a key role in the development of osteoporosis and cancer bone metastasis. The identification of novel and specific targets will be helpful for the development of new therapeutic strategies for bone metastasis in lung cancer. Herein, we examined microRNAs in tumor cell-derived exosomes to investigate the communication between the bone environment and tumor cells. TCGA database analysis showed that the level of miR-17-5p increased in non-small cell lung cancer tissues compare...
Source: Experimental Cell Research - Category: Cytology Authors: Source Type: research
Best Pract Res Clin Endocrinol Metab. 2021 Sep 10:101577. doi: 10.1016/j.beem.2021.101577. Online ahead of print.ABSTRACTThis narrative review analyses the customization of Menopause Hormone Therapy in the context of breast cancer risk in women with premature ovarian insufficiency (POI) and with menopause at a normal age. Women with Idiopathic POI, FMR-1 premutation or Turner syndrome, if left untreated, may have lower breast cancer risk compared to the healthy age-matched female population. These women should be treated with MHT until the age of 50, as the risk of breast cancer is equal to that of normally menstruating wo...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
ConclusionOverall, exercise regimens of studies included in this review appear to improve bone health at the hip and spine in people diagnosed with cancer. Sub-analyses suggest some influence of sex, where females had greater improvements in BMD compared to males. It is essential that future studies evaluate the dose –response of exercise training on bone health and create exercise protocols that better align with the laws of bone modelling to enhance osteogenic potential.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
ConclusionTrabecular microarchitecture assessed by TBS was similar between women on long-term suppressive therapy in DTC and those on LT4 replacement therapy aiming at a TSH level within the low-normal reference range. Low TBS values were observed in postmenopausal women of both groups, suggesting that not only suppressed TSH levels but also a low-normal TSH is associated with deteriorated bone microarchitecture in postmenopausal women following total thyroidectomy.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Adv Food Nutr Res. 2021;98:35-99. doi: 10.1016/bs.afnr.2021.02.005. Epub 2021 Mar 24.ABSTRACTPolyphenols are a kind of complex secondary metabolites in nature, widely exist in the flowers, bark, roots, stems, leaves, and fruits of plants. Numerous studies have shown that plant-derived polyphenols have a variety of bioactivities due to their unique chemical structure, such as antioxidant, antimicrobial, and prevention of chronic diseases, cardiovascular disease, cancer, osteoporosis, and neurodegeneration. With the gradual rise of natural product development, plant polyphenols have gradually become one of the research hotsp...
Source: Advances in Food and Nutrition Research - Category: Nutrition Authors: Source Type: research
ConclusionTrabecular microarchitecture assessed by TBS was similar between women on long-term suppressive therapy in DTC and those on LT4 replacement therapy aiming at a TSH level within the low-normal reference range. Low TBS values were observed in postmenopausal women of both groups, suggesting that not only suppressed TSH levels but also a low-normal TSH is associated with deteriorated bone microarchitecture in postmenopausal women following total thyroidectomy.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
More News: Cancer | Cancer & Oncology | Cardiology | Health Management | Heart | National Institutes of Health (NIH) | New York University | Orthopaedics | Osteoporosis | Statistics | Study | Universities & Medical Training | Women