The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy

Conclusions: Together, these findings suggest that the UPR exerts a protective effect in the setting of PLN R14del cardiomyopathy and that modulation of the UPR might be exploited therapeutically.PMID:33928785 | DOI:10.1161/CIRCULATIONAHA.120.049844

Source: Circulation - April 30, 2021 Category: Cardiology Authors: Dries A M Feyen Isaac Perea-Gil Renee G C Maas Magdalena Harakalova Alexandra A Gavidia Jennifer Arthur Ataam Ting-Hsuan Wu Aryan Vink Jiayi Pei Nirmal Vadgama Albert J Suurmeijer Wouter P Te Rijdt Michelle Vu Prashila L Amatya Maricela Prado Yuan Zhang L Source Type: research