Theranostic AGuIX nanoparticles as radiosensitizer: A phase I, dose-escalation study in patients with multiple brain metastases (NANO-RAD trial)

External radiotherapy is one of the main treatment in neuro oncology due to difficulty of surgery and uncertain distribution of systemic therapy. Despite advances in cancer treatments, however, no curative approaches exist for patients with multiple brain metastases. The use of radiation sensitizers would therefore be of great interest specifically in increasing the effects of RT in tumors while sparing surrounding healthy tissues as RT dose-escalation can significantly improve local tumor control and survival.

Source: Radiotherapy and Oncology - May 4, 2021 Category: Radiology Authors: Camille Verry, Sandrine Dufort, Julie Villa, Marylaure Gavard, Carole Iriart, Sylvie Grand, Julie Charles, Benoit Chovelon, Jean-Luc Cracowski, Jean-Louis Quesada, Christophe Mendoza, Lucie Sancey, Audrey Lehmann, Florence Jover, Jean-Yves Giraud, Fran ç Tags: Original Article Source Type: research