Juvenile idiopathic inflammatory myopathies with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies in a Chinese cohort

CONCLUSIONS: Our study indicates that anti-HMGCR antibodies may not be rare in Chinese JIIM. These anti-HMGCR-positive JIIMs were characterized by acute onset, substantially elevated creatine kinase level, and skin lesions without perifascicular changes in muscle pathology. The treatment outcome is generally favorable with the combination of steroid and immunosuppressant.PMID:33932258 | DOI:10.1111/cns.13658

Source: CNS Neuroscience and Therapeutics - May 1, 2021 Category: Neuroscience Authors: Ying Hou Kai Shao Bing Zhao Tingjun Dai Qinzhou Wang Yuying Zhao Chuanzhu Yan Yaping Yan Xiaotian Ma Wei Li Source Type: research