Pharmacological inhibition of dynamin ‐related protein 1 attenuates skeletal muscle insulin resistance in obesity

In conclusion, inhibiting Drp1 with short‐term Mdivi‐1 administration attenuates the impairment in skeletal muscle insulin signaling and improves whole‐body glucose tolerance in the setting of obesity‐induced insulin resistance. Targeting Drp1 may be a viable approach to treat obesi ty‐induced insulin resistance.

Source: Physiological Reports - April 27, 2021 Category: Physiology Authors: Benjamin A. Kugler, Wenqian Deng, Abigail L. Duguay, Jessica P. Garcia, Meaghan C. Anderson, Paul D. Nguyen, Joseph A. Houmard, Kai Zou Tags: ORIGINAL ARTICLE Source Type: research