PHLDA3 inhibition attenuates endoplasmic reticulum stress-induced apoptosis in myocardial hypoxia/reoxygenation injury by activating the PI3K/AKT signaling pathway

In conclusion, in the process of H/R injury, PHLDA3 inhibition reduced ERS-induced apoptosis and H/R injury by activating the PI3K/AKT pathway. PHLDA3 may be a therapeutic target for the treatment of MIRI.PMID:33936270 | PMC:PMC8082641 | DOI:10.3892/etm.2021.10045
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research