Clinical characteristics of Pseudomonas and Aspergillus co-infected cystic fibrosis patients: A UK registry study

Cystic fibrosis (CF) is a common, life-limiting, autosomal-recessive disease associated with airway damage and a progressive functional decline in respiratory health [2]. The underlying genetic defect leads to the presence of thick, tenacious mucus and reduced airway mucociliary clearance resulting in inflammation and infection with a complex polymicrobial community that adapts to become persistent [3 –5]. Pseudomonas aeruginosa (Pa), a highly versatile Gram-negative bacterium, remains the most common airway pathogen in CF patients.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research