Mayo Clinic Q & amp;A podcast: Reducing rejection by reversing order of heart-liver transplant

For heart-liver transplants, the liver and heart must come from the same donor, and some patients wait years to receive both organs. Also, antibodies from the donor can increase chances of the receiving patient rejecting the heart. But Dr. Sudhir Kushwaha, a Mayo Clinic cardiovascular transplant surgeon, says when a liver transplant is also involved, [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news

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AbstractBackground and objective The main objective was to evaluate the impact of Hepatitis C Virus treatment with direct-acting antiviral agents on tacrolimus blood levels in recipients of kidney and heart allografts.Method We analysed Hepatitis C Virus infected adult patients who received tacrolimus as immunosuppressive maintenance therapy and received direct-acting antiviral agents treatment in a tertiary hospital with solid transplant multidisciplinary program in Madrid, Spain. Liver and renal function, tacrolimus dose and blood levels were analysed before and 12  weeks after the end of treatment.Results We identi...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
Purpose of review Accumulating evidence supports the important contribution of volume-related metrics to morbidity and mortality in patients receiving chronic haemodialysis. The purpose of this review is to summarize recent advances in the understanding and management of volume status in this high-risk group. Recent findings Delivery of optimal volume management involves three key components: accurate estimation of volume status, correction of extracellular fluid overload and prevention of intradialytic instability. The lack of a gold standard for assessing volume status makes accurate estimation difficult to achieve;...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: DIALYSIS AND TRANSPLANTATION: Edited by David J. Cohen Source Type: research
Conclusion: CPSS may be a more likely cause of unexplained PAH in pediatric patients than previously thought. Shunt closure or liver transplantation may prevent the progression of PAH, or even improve it for the majority of CPSS patients.What is Known:•Congenital portosystemic shunts (CPSS) are increasingly recognized as a cause of pulmonary arterial hypertension (PAH) in children, but the prevalence of CPSS in pediatric PAH patients is largely unknown, and the therapeutic outcomes of these conditions are not well described.What is New:•This is the largest cohort of CPSS-associated PAH ever published. CPSS may be...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Fewer than 25 simultaneous heart-liver-kidney transplants (SHLKTxs) have been performed in the U.S. This highly complex operation was performed nine times by only four centers from 2018 to 2019. However, one institution, the University of Chicago Medical Center (UCMC), is responsible for two-thirds of all SHLKTxs performed in that period. There is a paucity of literature regarding the logistics and infrastructure of performing SHKLTxs. The development of a standardized, effective protocol would improve outcomes in the high-risk patients who undergo this operation.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 455 Source Type: research
Hepatitis E viral infection recently emerges as a global health concern. Over the last decade, the understanding of hepatitis E virus (HEV) had changed with the discovery of new genotypes like genotype-7 and genotype-8 with associated host and mode of infection. Diversification in the mode of hepatitis E infection transmission through blood transfusion, and organ transplants in contrast to classical feco-oral and zoonotic mode is the recent medical concern. The wide spectrum of infection ranging from self-limiting to acute liver failure is now overpowered by HEV genotype-specific chronic infection especially in transplant ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
If you ask health care providers about the most challenging condition to treat, chronic pain is mentioned frequently. By its nature, chronic pain is a complex and multidimensional experience. Pain perception is affected by our unique biology, our mood, our social environment, and past experiences. If you or a loved one is suffering from chronic pain, you already know the heavy burden. People are looking for novel, nonaddictive ways to treat pain Given the ongoing challenges of chronic pain management coupled with the consequences of the opioid epidemic, pain management practitioners and their patients are searching for eff...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Back Pain Marijuana Pain Management Source Type: blogs
To describe the assessment of Fontan associated liver disease and determine the clinical and imaging measures that may identify hepatic morbidity risk in isolated heart transplantation candidates and trend those measures post-IHT.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Articles Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractATTR amyloidosis is caused by systemic deposition of transthyretin (TTR) and comprises ATTRwt (wt for wild-type) amyloidosis, ATTRv (v for variant) amyloidosis, and acquired ATTR amyloidosis after domino liver transplantation. ATTRwt amyloidosis has classically been regarded as cardiomyopathy found in the elderly, whereas carpal tunnel syndrome has also become a major initial manifestation. The phenotypes of ATTRv amyloidosis are diverse and include neuropathy, cardiomyopathy, and oculoleptomeningeal involvement as the predominant features, depending on the mutation and age of onset. In addition to variant TTR, the...
Source: Neurology and Therapy - Category: Neurology Source Type: research
In the growing population of adults with congenital heart disease (CHD) heart failure (HF) remains the leading cause of premature death [1]. Pharmacological therapy and assist devices are used with limited success and heart transplantation represents the final option for a select number of patients with end-stage CHD. However, transplant programs in this unique population are challenged due to specific considerations such as previous operations and sternotomies, human leucocyte antigen (HLA) sensitisation, complex cardiac anatomies and skeletal abnormalities, pulmonary vascular disease, reasons to require transplantation i...
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
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