Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial

Conclusions: Neither denosumab nor alendronic acid affected progression of aortic valve calcification in patients with calcific aortic stenosis. Alternative pathways and mechanisms need to be explored to identify disease-modifying therapies for the growing population of patients with this potentially fatal condition. Clinical Trial Registration: https://www.clinicaltrials.gov Unique Identifier: NCT02132026.PMID:33913339 | DOI:10.1161/CIRCULATIONAHA.121.053708

Source: Circulation - April 29, 2021 Category: Cardiology Authors: Tania A Pawade Mhairi K Doris Rong Bing Audrey C White Laura Forsyth Emily Evans Catriona Graham Michelle C Williams Edwin J R van Beek Alison Fletcher Philip D Adamson Jack P M Andrews Timothy R G Cartlidge William S A Jenkins Maaz Syed Takeshi Fujisawa Source Type: research