Different Immunohistochemical Localization of Fatty Acid Binding Protein 5 in Actinic Keratosis Compared with That in Bowen's Disease: A Retrospective Study

This study is the first to investigate the role of FABP5 in premalignant skin lesions. The unique immunohistochemical localization of the FABP5 can be a helpful diagnostic marker, and altered fatty acid metabolism may be the key in understanding the different pathophysiology of AK and BD.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research

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Conclusion: The incidence of penile and anal high-grade intraepithelial neoplasia and SCC in men with diabetes was increased compared with men without diabetes. For penile and anal SCCs, this was primarily due to an increased risk in men with T2D.
Source: Epidemiology - Category: Epidemiology Tags: Infectious Diseases Source Type: research
Condition:   Cutaneous Squamous Cell Carcinoma Intervention:   Drug: Imgatuzumab Sponsors:   Pega-One S.A.S.;   ICON plc Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: The response and disease control to ICIs may differ in ESCC tumors located at different metastatic sites, with a lesser likelihood of response and disease control in metastatic liver tumors than in tumors located at the LNs and lung.Oncology
Source: Oncology - Category: Cancer & Oncology Source Type: research
Cancer Biomark. 2021 Jul 20. doi: 10.3233/CBM-203043. Online ahead of print.ABSTRACTBy using a meta-analytical approach, this study aimed to analyse the diagnostic capacity of protein-based biomarkers in saliva for the differential diagnosis of oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) from healthy individuals as control group (HCG).Articles on protein-based biomarkers in saliva, which provided quantitative expression in individuals with clinical and histopathological diagnosis of OPMD or oral leukoplakia (OL) were considered eligible. Searches were conducted in eight electronic d...
Source: Cancer Biomarkers - Category: Cancer & Oncology Authors: Source Type: research
Nutr Cancer. 2021 Aug 2:1-12. doi: 10.1080/01635581.2021.1952449. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma is a malignant tumor that is difficult to find and has a poor prognosis. The aim of this study is to explore the chemoprevention effect of Astaxanthin (AST) and reveal the possible mechanism of AST on the development of esophageal cancer based on PPARγ. We found that a stable and strong binding between PPARγ molecules and AST molecules using Autodock 4.0 software. AST significantly inhibited the viability of EC109 cells in a dose and time dependent manners (all P
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Source Type: research
In this study, we assessed the diagnostic value of autoantibodies against p53, MMP-7, and Hsp70 in skin SCC and BCC. ELISA was performed to detect levels of autoantibodies in sera from 101 NMSC patients and 102 normal controls, who were recruited from the Cancer Hospital of Shantou University Medical College. A receiver operator characteristic curve was used to evaluate the diagnostic value. The serum levels of autoantibodies against p53, MMP-7, and Hsp70 were higher in NMSCs than those in the normal controls (all P
Source: Disease Markers - Category: Laboratory Medicine Authors: Source Type: research
CONCLUSION: Our study highlighted the significance of the TSPEAR-AS2/miR-487a-3p/PPM1A axis within OSCC progression and offered a novel biomarker and novel strategies for OSCC treatments.PMID:34336002 | PMC:PMC8313349 | DOI:10.1155/2021/2217663
Source: Disease Markers - Category: Laboratory Medicine Authors: Source Type: research
CONCLUSION: Thus, NR2F1-AS1 was verified to regulate GC cell progression by sponging miR-493-5p to upregulate MAP3K2 expression.PMID:34335755 | PMC:PMC8294992 | DOI:10.1155/2021/3881932
Source: Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: Metformin inhibits HSCC progression through the circ_0003214/miR-489-3p/ADAM10 pathway.PMID:34335751 | PMC:PMC8295003 | DOI:10.1155/2021/2265475
Source: Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research
Cancer Biomark. 2021 Jul 20. doi: 10.3233/CBM-203043. Online ahead of print.ABSTRACTBy using a meta-analytical approach, this study aimed to analyse the diagnostic capacity of protein-based biomarkers in saliva for the differential diagnosis of oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) from healthy individuals as control group (HCG).Articles on protein-based biomarkers in saliva, which provided quantitative expression in individuals with clinical and histopathological diagnosis of OPMD or oral leukoplakia (OL) were considered eligible. Searches were conducted in eight electronic d...
Source: Cancer Biomarkers : Section A of Disease Markers - Category: Cancer & Oncology Authors: Source Type: research
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