The role of decreased cortical thickness and volume of medial temporal lobe structures in predicting incident psychosis in patients with Alzheimer's disease: a prospective longitudinal MRI study

Psychotic symptoms are among the most common non-cognitive neuropsychiatric symptoms seen in Alzheimer's disease (AD) and have been reported to occur in approximately 25-41 % of patients with AD.1-3 The presence of psychotic symptoms in AD portends a more severe course of cognitive decline,4 increases the burden on the caregiver,5 and often results in early institutionalization6 of patients with AD. Given the limited efficacy over placebo7 and high incidence of adverse effects8 of antipsychotic drugs prescribed for AD, identifying the underlying neurobiological mechanism is critical for early diagnosis and prediction of the progression of AD.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research