Infection-associated peripheral nerve hyperexcitability: An under-recognized entity

Conclusion: There appears to be a definitive link between staphylococcal infection (MRSA in particular) and development of PNH. The temporal evolution of PNH associated with the infection and resolution following treatment of the infection does support a causal association. The enterotoxins produced by staphylococci act as superantigens and could trigger an inflammatory cascade along with development of cross reacting antibodies against VGKC in peripheral nerves. Future studies with animal models could provide more directions in this regard.

Source: Annals of Indian Academy of Neurology - April 28, 2021 Category: Neurology Authors: Ajith Sivadasan Aditya Nair Angel Miraclin Arun Mathai Mani AT Prabhakar John Antony Jude Prakash Vivek Mathew Source Type: research