The effect of consanguinity on coalescence times on the X chromosome

We describe a consanguinity effect on X-chromosomal TMRCA that differs from the autosomal pattern under matrilateral but not under patrilateral first-cousin mating. For matrilateral first cousins, the effect of consanguinity in reducing TMRCA is stronger on the X chromosome than on the autosomes, with an increased effect of parallel-cousin mating compared to cross-cousin mating. The theoretical computations support the utility of the model in understanding patterns of genomic sharing on the X chromosome.PMID:33901539 | DOI:10.1016/j.tpb.2021.03.004

Source: Theoretical Population Biology - April 26, 2021 Category: Biology Authors: Daniel J Cotter Alissa L Severson Noah A Rosenberg Source Type: research