Blood-brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses [Immunology and Inflammation]

Intracarotid arterial hyperosmolar mannitol (ICAHM) blood–brain barrier disruption (BBBD) is effective and safe for delivery of therapeutics for central nervous system malignancies. ICAHM osmotically alters endothelial cells and tight junction integrity to achieve BBBD. However, occurrence of neuroinflammation following hemispheric BBBD by ICAHM remains unknown. Temporal proteomic changes in rat...

Source: Proceedings of the National Academy of Sciences - April 27, 2021 Category: Science Authors: Scott R. Burks, Cymon N. Kersch, Jaclyn A. Witko, Michael A. Pagel, Maggie Sundby, Leslie L. Muldoon, Edward A. Neuwelt, Joseph A. Frank Tags: Immunology and Inflammation Biological Sciences Source Type: research