Evaluation of the Efficacy and Safety of a 4-month Daily Regimen (2HZPM/2HPM) for Treatment of Pulmonary TB

Condition:   Tuberculosis, Pulmonary Intervention:   Drug: 4-month rifapentine-based regimen Sponsors:   Kaohsiung Veterans General Hospital.;   National Taiwan University;   Taipei Veterans General Hospital, Taiwan;   Chang Gung Memorial Hospital;   Centers for Disease Control, Taiwan Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Publication date: Available online 9 October 2020Source: Microbiological ResearchAuthor(s): M.A. Abo-Kadoum, Mohammed Assad, Yongdong Dai, Nzungize Lambert, Ulrich Aymard Ekomi Moure, Adel Eltoukhy, Stech A.E. Nazou, Asmaa Moaaz, Jianping Xie
Source: Microbiological Research - Category: Infectious Diseases Source Type: research
Publication date: November 2020Source: Molecular Immunology, Volume 127Author(s): Krisna Moorthi Periyasamy, Uma Devi Ranganathan, Srikanth Prasad Tripathy, Ramalingam Bethunaickan
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
[Leadership] Chevron has revealed that it is spending over $5 million (about N1.9 billion) to support the federal government's fight against tuberculosis, malaria and HIV in the country since 2017.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
ACC Abstract Tuberculosis of the skull or calvarial tuberculosis (CTB) is rare. The literature until 2019 reported less than 60 cases of CTB in childhood. The authors describe two patients with CTB associated with other manifestations of TB, such as: spine and rib injuries, peripheral adenopathy, hepatic and splenic involvement who improved with chemotherapy. The patients were a four-year-old and an eight-year-old child, whose diagnoses were confirmed by histopathological, bacteriological or molecular investigation. Both were not infected with the human immunodeficiency virus (HIV) and did not need orthopedic tre...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
Rationale: Mycobacterium tuberculosis (TB) remains a serious threat in developing countries. Primary isolated hepatic tuberculosis is extremely rare. Because of its non-specific imaging features, noninvasive preoperative imaging diagnosis of isolated hepatic tuberculoma remains challenging. Patient concerns: A 48-year-old man was admitted to our hospital due for suspected liver neoplasm during health examination. Diagnoses: The tests for blood, liver function, and tumor markers were within normal range. Preoperative ultrasonography (US) showed a hypoechoic lesion with a longitudinal diameter of 2.5 cm in segment ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
The triple burden of COVID-19, tuberculosis and human immunodeficiency virus is one of the major global health challenges of the twenty-first century. In high burden HIV/TB countries, the spread of COVID-19 am...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Mycobacterium tuberculosis (M. tb), the intracellular pathogen causing tuberculosis, has developed mechanisms that endow infectivity and allow it to modulate host immune response for its survival. Genomic and proteomic analyses of non-pathogenic and pathogenic mycobacteria showed presence of genes and proteins that are specific to M. tb. In silico studies predicted that M.tb Rv1954A is a hypothetical secretory protein that exhibits intrinsically disordered regions and possess B cell/T cell epitopes. Treatment of macrophages with Rv1954A led to TLR4-mediated activation with concomitant increase in secretion of pro-inflammat...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
We present a conceptual and empirical approach for estimating these functions, allowing for nonconstant marginal costs. We aim to expand on the current approach which commonly assumes linearity of cost over scale.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research
[Nation] Health experts are now warning of a surge in tuberculosis (TB) cases in the country.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Authors: Thomas BE, Stephen A PMID: 33021117 [PubMed - as supplied by publisher]
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
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