P146  Investigating the role of T regulatory cells in the amelioration of RA in pregnancy

Conclusion We found a significant increase in activation of Tregs measured by CD69 in T3 of both pregnancy groups, implying that the pregnant state enhances the function of these cells and may thus lead to amelioration of RA. Although disease activity measured by DAS28(3)CRP and MSK-US was not correlated wi th Treg activation in T3, the strong negative correlation of these scores with %FOXP3+ Tregs in PP may link a decline in their suppressive function with PP flare. Further work is underway to clarify these findings.Disclosure C. Raine: Grants/research support; CR has received funding for research from UCB.G. Robinson: None.E.C. Jury: None.I. Giles: Grants/research support; IG has received an unrestricted educational grant, speaker's fees and travel fees from UCB.
Source: Rheumatology - Category: Rheumatology Source Type: research