Model reduction for initial value ODEs

In this study we extend an algorithm for automatically simplifying systems of initial value ordinary differential equations (Whiteley (2010)) that is based on a posteriori analysis of the full system of equations. Our extensions to the algorithm make the following contributions: (i) each equation in a system of differential equations may be written as a finite sum of contributions (including the derivative term), and any one of these terms may be neglected (if it is appropriate to do so) in the simplified model; and (ii) a simplified model is generated that allows accurate prediction of one or more components of the solution at all times. These extensions are illustrated using examples drawn from enzyme kinetics and cardiac electrophysiology.PMID:33878304 | DOI:10.1016/j.mbs.2021.108618
Source: Mathematical Biosciences - Category: Statistics Authors: Source Type: research