Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD)

Chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) are common comorbidities, affecting 40-70% [1 –4] and 2-11% [5,6] of lung cancer patients, respectively. Previous studies have shown a higher mortality rate and lower quality-of-life post-radiotherapy in lung cancer patients with co-existent COPD [7–9] and ILD [10–15].Oncological treatment of lung cancer in patients with underlying respir atory co-morbiditiesis challenging due to a higher risk of post-radiotherapy side-effects, including atypical infections, exacerbation of COPD/ILD symptoms and fulminant radiation pneumonitis/fibrosis, all of which are potentially life-threatening [14,16].

Source: Radiotherapy and Oncology - April 23, 2021 Category: Radiology Authors: Celion Tang, Hitesh Mistry, Neil Bayman, Clara Chan, David Cobben, Corinne Faivre-Finn, Margaret Harris, Jason Kennedy, Laura Pemberton, Gareth Price, Hamid Sheikh, David Woolf, Joanna Coote, Ahmed Salem Tags: Short Communication Source Type: research