New Phase 3 Data Showed First-in-Class TREMFYA ® (guselkumab) Provided Durable Complete Skin Clearance Through Five Years in Moderate to Severe Plaque Psoriasis (PsO) and Robust Joint Symptom Improvement Through 52 Weeks in Active Psoriatic Arthritis (PsA)

SPRING HOUSE, PENNSYLVANIA, April 23, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced new Phase 3 data which showed TREMFYA® (guselkumab) sustained durable, complete skin clearance rates in a majority of adults with moderate to severe plaque psoriasis (PsO) through five years (252 weeks), a and improved disease activity and axial symptoms in adults with active psoriatic arthritis (PsA) through one year (52 weeks).1,2,3 These data are being presented at the American Academy of Dermatology Virtual Meeting Experience 2021, where Janssen will present a total of 22 abstracts. TREMFYA is the first and only selective interleukin (IL)-23 inhibitor therapy approved in the U.S. to treat both adults with moderate to severe plaque PsO who are candidates for systemic therapy or phototherapy and adults with active PsA.4 “People living with psoriatic disease can face a lifetime of physical pain and discomfort, which places a significant burden on their lives,” said Kristian Reich,b M.D., Ph.D., Professor of Translational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Germany, and lead author of the VOYAGE 2 study. “The signs and symptom improvements seen with TREMFYA are noteworthy for both patients who live with fear of disease recurrence and their physicians, as these data add to a growing body of evidence for this first-i...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news

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Mandatory mask-wearing in shops and transport reimposed in England;Anthony Fauci says new variant is probably already in the US;Australia scrambles to prevent outbreakJohnson ignored my plan to deal with new variants – ex-officialOmicron ’s worst impact will be in nations with low vaccination ratesWhat do we know about the new ‘worst ever’ Covid variant?See all our coronavirus coverageAustralian states and territories are braced for the spread of Omicron, with authorities conceding on Sunday that positive cases were inevitable.Both the NSW and Victorian governments have introduced 72-hour isolation ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: World news Coronavirus Science UK news Europe US news Source Type: news
ConclusionThe e-TEP-RS technique for large, complex, midline, ventral abdominal hernias can be used with excellent results and acceptable morbidity. This technique is technically challenging and should be mastered in relatively smaller ventral hernias to achieve good results before attempting it in larger, complex ones.
Source: Hernia - Category: Sports Medicine Source Type: research
AbstractAimTo analyze the outcomes of component separation techniques (CST) to treat incisional hernias (IH) in a large multicenter cohort of patients.MethodsAll IH repair using CST, registered in EVEREG from July 2012 to December 2019, were included. Data on the pre-operative patient characteristics and comorbidities, IH characteristics, surgical technique, complications, and recurrence were collected. Outcomes between anterior (ACS) and posterior component separation (PCS) techniques were compared. Risk factors for complications and recurrences were analyzed.ResultsDuring the study period, 1536 patients underwent CST (45...
Source: Hernia - Category: Sports Medicine Source Type: research
This study evaluates the effectiveness of two postoperative analgesia modalities: epidural cat heter and surgeon-performed TAP-block following VHR performed with transversus abdominis release (TAR).MethodsA retrospective analysis was performed on data prospectively collected between 2012 and 2019. All patients undergoing open VHR with TAR performed by a single surgeon were identified. Parastomal hernia repairs and any patients receiving ultrasound-guided TAP blocks or paraspinal blocks were excluded. Primary outcome was length of stay (LOS) with secondary outcomes including pain scores, opioid requirements, and 30-day morb...
Source: Hernia - Category: Sports Medicine Source Type: research
Asya, 35, of south London, contracted Covid in December and was forced to deliver her son, Daniel, dangerously early at 27-and-a-half weeks.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
A new coronavirus variant, first discovered in South Africa, has begun to spread around the globe. Vaccine producers say they're working to get ahead of the new strain.(Image credit: Denis Farrell/AP)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
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