Perirhinal cortex and the recognition of relative familiarity

We present two studies that explore cellular activity (through c-fos imaging) within perirhinal cortex of rats performing SOR where the familiarity of objects has been manipulated. Despite robust recognition memory performance, we show no significant changes in perirhinal activity related to the level of familiarity of the objects. Reasons for this lack of familiarity-related modulation in perirhinal cortex activity are discussed. The current findings support emerging evidence that perirhinal responses to novelty are complex and that task demands are critical to the involvement of perirhinal cortex in the control of object recognition memory.PMID:33862223 | DOI:10.1016/j.nlm.2021.107439
Source: Neurobiology of Learning and Memory - Category: Neurology Authors: Source Type: research