Notch Signaling Pathway: Find New Channel during Liver Repair and Regeneration

Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419123200. Online ahead of print.ABSTRACTThe liver is one of the significant regenerative organs in the body. Nevertheless, underlying molecular mechanisms regulating liver repair and regeneration following resection or damage remain largely unknown. The Notch signaling pathway is a profoundly evolutionarily well-conserved cell signaling system that plays mostly in multicellular organisms' development. Malfunctions in this pathway lead to the progression of several liver disorders, including hepatoblastoma (HB), cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), and so on. Notch pathway plays a fundamental role in cell fate during the embryonic stage's progression to the adult stage in liver tissue. Modulation of Notch signaling may be used in the vast array of patients who succumb to cirrhosis owing to chronic hepatitis by virus infection. This review describes the underlying mechanisms of the Notch signaling pathway in liver development and regeneration briefly and discusses how this pathway leads to better liver disorders in the clinic.PMID:33874861 | DOI:10.2174/0929867328666210419123200
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research