Regulation of Protein Synthesis: an Approach to Treat Autistic Spectrum Disorder (ASD)

Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419125634. Online ahead of print.ABSTRACTAutistic Spectrum Disorder (ASD) is a disorder with different etiologies and poor elucidation, characterized by changes in social and cognitive skills. ASD has been characterized that affect large numbers of people in the world. In spite of its great importance, surprisingly just a modest progress has been achieved toward comprehending this pathology and designing new therapies. The molecular dysfunctions observed in people with autism are evidenced by the interference in the synthesis of synaptic proteins, which impairs their development and plasticity, leading to characteristics of individuals with ASD. The present work investigates in detail the mTOR pathway and the proteins related to its regulation and neurological functioning. The path of protein synthesis and translation is promising for the treatment of various disorders and its elucidation may, for example, result in drugs that facilitate the diagnosis and open the range of treatments, improving the quality of life of ASD patients.PMID:33874864 | DOI:10.2174/0929867328666210419125634
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research