Protecting P-type plasma membrane H+-ATPases from ROS

Biochem J. 2021 Apr 30;478(8):1511-1513. doi: 10.1042/BCJ20210109.ABSTRACTP-type ATPase are ubiquitous transport proteins across all kingdoms of life. These proteins share a common mechanism involving phosphorylation of an invariant aspartate to facilitate movement of substrates from protons to phospholipids across cellular membranes. In this issue of the Biochemical Journal, Welle et al. identify a conserved cysteine near the functionally critical aspartate of P-type plasma membrane H+-ATPases that protects the protein from reactive oxygen species.PMID:33881485 | DOI:10.1042/BCJ20210109
Source: The Biochemical Journal - Category: Biochemistry Authors: Source Type: research
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