Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs [Medical Sciences]

Cancer cells can survive chemotherapy-induced stress, but how they recover from it is not known. Using a temporal multiomics approach, we delineate the global mechanisms of proteotoxic stress resolution in multiple myeloma cells recovering from proteasome inhibition. Our observations define layered and protracted programs for stress resolution that encompass extensive...

Source: Proceedings of the National Academy of Sciences - April 21, 2021 Category: Science Authors: Paula Saavedra–Garcia, Monica Roman–Trufero, Hibah A. Al–Sadah, Kevin Blighe, Elena Lopez–Jimenez, Marilena Christoforou, Lucy Penfold, Daria Capece, Xiaobei Xiong, Yirun Miao, Katarzyna Parzych, Valentina S. Caputo, Alexandros P. Tags: Medical Sciences Biological Sciences Source Type: research