Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [ < sup > 35 < /sup > S]GTP γS binding assays combined with immunoprecipitation

In conclusion, [35S]GTPγS binding combined with antibody-mediated immunodetection represents an useful method to separately evaluate the functional activity of drugs acting on GPCRs over each Gα-protein subtype.PMID:33876404 | DOI:10.1007/s43440-021-00253-z
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Source Type: research