Geometric Analysis to Determine Kinking and Shortening of Bridging Stents After Branched Endovascular Aortic Repair

AbstractPurposeTo evaluate bridging stent geometry in patients who underwent branched endovascular aortic repair (B-EVAR) and to correlate the outcomes with intrinsic bridging stent characteristics aiming to identify the stent(s) that guarantees the best performance.MethodsPre-operative and post-operative computed tomography images of all patients undergoing B-EVAR between September 2016 and April 2019 were retrospectively analyzed. Following geometrical features were measured: target vessel take-off angle (TOA); longitudinal stent shortening; shape index (SI), intended as ratio between minimum and maximum diameter of the lumen cross sections, averaged on three segments: zone 1 (proximal stented zone), zone 2 (intermediate), and zone 3 (distal).ResultsThirty-eight branches (8 right (RRA) and 8 left renal arteries (LRA), 11 superior mesenteric arteries (SMA), 11 celiac trunks (CTR)) were treated. Fluency (Bard Peripheral Vascular), COVERA (Bard Peripheral Vascular), and VBX (WLGore&Assoc) stent-grafts were implanted in 10, 12, and 16 branches, respectively. Pre-operative TOA was more acute in RRA and LRA when compared to CTR and SMA, and straightened in post-operative configuration (109.86  ± 28.65° to 150.27 ± 21.0°;P 
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research

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ConclusionPatients with CD with more than 3 years of symptoms, more often have atypical presentation, anemia, pubertal delay, and more advanced histological changes. They also have fewer physician and gastroenterologist consultations. This underlines the need for proper awareness to ensure early diagnosis and treatment.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Several groups have described a subset of CD8 T cells with immunosuppressive characteristics in inflammatory disease settings. The increased prevalence of a defined subset of CD8 T cells and correlation to disease has been reported in mouse and human autoimmune diseases, suggesting a protective role for select CD8 T cells in autoimmunity. We hypothesized that a dysregulated regulatory CD8 T cell (CD8 Treg) network was similarly involved in the pathology of autoimmune diseases of the gut, including Celiac disease, Crohn ’s, and Ulcerative Colitis.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Innate and Mucosal Immunology and Immunity Source Type: research
CONCLUSIONS: In individuals with chronic diarrhea for more than three months, the prevalence of celiac disease was determined to be 12.2% (n=23). There was a statistically significant difference between those with a positive family history of CD and those who did not have the condition.PMID:35047307 | PMC:PMC8760010 | DOI:10.7759/cureus.20495
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
iar Churruca Arrate Lasa The present work aimed to analyze, through the GlutenFreeDiet digital platform, the evolution over one year of the nutritional status, dietary profile and symptoms present among celiac people on a gluten-free diet (GFD) while receiving individualized dietary advice. Twenty-seven adults and thirty-one celiac children/adolescents participated in the study. This was then followed up by three visits, at diagnosis, and after 3 and 12 months (vt0, vt3 and vt12). Participants filled out dietary and gastrointestinal symptoms questionnaires. All patients received written personalized dietary advice fr...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Gluten-free diet usually leads to mucosal remission in celiac disease, but persistent symptoms are common. Low FODMAP diet is an established treatment for irritable bowel syndrome (IBS). We have assessed the efficacy of a moderately low FODMAP diet on persistent symptoms in treated celiac patients.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
AbstractCoeliac disease is an immune-mediated condition characterized by chronic inflammation of the small bowel with villous atrophy driven by gluten ingestion in genetically predisposed individuals. It occurs frequently in both children and adults, affecting 1 –4% of the population. The disease is associated with both gastrointestinal and extra-intestinal symptoms related to malabsorption and/or immune activation, and autoantibodies to tissue transglutaminase. Removal of gluten from the diet results in resolution of symptoms and enteropathy in the majo rity of patients. A good diagnostic work-up is important t...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Food Funct. 2022 Jan 14. doi: 10.1039/d1fo00490e. Online ahead of print.ABSTRACTGluten Friendly™ (GF) is a new gluten achieved through a physicochemical process applied to wheat kernels. The goal of this research was to assess the in vivo effects of Gluten Friendly™ bread on celiac gut mucosa and microbiota. In a double-blind placebo-controlled intervention study, 48 celiac disease (CD) patients were randomized into 3 groups to eat 100 g of bread daily, containing different doses (0; 3 g; 6 g) of GF for 12 weeks. The small-bowel morphology (VH/CrD), intraepithelial densities of CD3+, celiac serology, MUC2, CB1,...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Mucosal Immunology, Published online: 14 January 2022; doi:10.1038/s41385-021-00479-3The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential
Source: Mucosal Immunology - Category: Allergy & Immunology Authors: Source Type: research
Clin Exp Immunol. 2021 Nov 18:uxab010. doi: 10.1093/cei/uxab010. Online ahead of print.ABSTRACTEvaluating the usefulness of intestinal anti-transglutaminase IgA (anti-TG2 IgA) deposits detection as a complementary or decision-supporting tool in the diagnosis of celiac disease (CD) in patients with low degree of enteropathy. Small intestinal biopsies (SIB) were performed from 2008 to 2017 in patients on suspicion of CD (positive CD serology and/or symptoms) referred to our Pediatric Gastroenterology Unit. We determined anti-TG2 IgA deposits by using double immunofluorescence in all the patients in whom Marsh 0 or Marsh1 was...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Source Type: research
Condition:   Celiac Disease Interventions:   Diagnostic Test: iVYCHECK GIP Urine;   Diagnostic Test: CeliacDetect Sponsors:   Biomedal S.L.;   University of Seville;   FUNDACION IHP Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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