Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells

CONCLUSION: Considering that TLR3 signaling is implicated, at least in part, in LN pathogenesis, our results suggest that anti-malarial agents exert a protective effect against the development of inflammation in GECs, as postulated in LN. Interestingly, CQ is a rather powerful inhibitor compared with HCQ on TLR3 signaling-induced chemokine expression in GECs. In turn, these findings may further support the theory that the use of HCQ is safer than CQ in a clinical setting. However, further detailed studies are needed to confirm our preliminary findings.PMID:33820486 | DOI:10.1080/0886022X.2021.1908901

Source: Renal Failure - April 6, 2021 Category: Urology & Nephrology Authors: Riko Sato Tadaatsu Imaizumi Tomomi Aizawa Shojiro Watanabe Koji Tsugawa Shogo Kawaguchi Kazuhiko Seya Tomoh Matsumiya Hiroshi Tanaka Source Type: research