The Role of Cholesterol Homeostasis in Diabetic Kidney Disease

Curr Med Chem. 2021 Apr 19. doi: 10.2174/0929867328666210419132807. Online ahead of print.ABSTRACTConsiderable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity, and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury and microalbuminuria of diabetic kidney disease. In the review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney dysfunction in diabetic kidney disease.PMID:33874866 | DOI:10.2174/0929867328666210419132807
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research