Inflammatory Gene Expression of Human Perivascular Adipose Tissue in Abdominal Aortic Aneurysms

CONCLUSION: The data revealed that PVAT from AAA shows an increased pro-inflammatory and matrix metallopeptidase gene expression and decreased anti-inflammatory gene expression. Furthermore, increased expression of genes involved in aneurysm formation was found in healthy SMC co-culture with PVAT of AAA patients. Therefore, PVAT from AAA might contribute to inflammation of the adjacent aortic wall and thereby plays a possible role in AAA pathophysiology. These proposed pathways of inflammatory induction could reveal new therapeutic targets in AAA treatment.PMID:33858751 | DOI:10.1016/j.ejvs.2021.02.034

Source: PubMed: Eur J Vasc Endovasc ... - April 16, 2021 Category: Surgery Authors: Jorn P Meekel Marina Dias-Neto Natalija Bogunovic Gloria Concei ção Claudia Sousa-Mendes Gawin R Stoll Adelino Leite-Moreira Jennifer Huynh Dimitra Micha Etto C Eringa Ron Balm Jan D Blankensteijn Kak K Yeung Source Type: research