Pathogenesis of Pulmonary Hemorrhagic Syndrome in Human Leptospirosis

Am J Trop Med Hyg. 2021 Apr 19:tpmd201000. doi: 10.4269/ajtmh.20-1000. Online ahead of print.ABSTRACTBased on a previous study and by incorporating new knowledge, the goal of our study was to understand more fully the pathogenesis of hemorrhagic pneumonia of severe human leptospirosis, highlighting the onset of capillary lesions by Leptospira itself and/or its antigenic/toxic products acting on the endothelium and binding to cadherins. Both events lead to loss of endothelial integrity, alter permeability, cause rupture, and open intercellular junctions, contributing to the hemorrhagic phenomena associated with severe leptospirosis.PMID:33872210 | DOI:10.4269/ajtmh.20-1000
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Source Type: research