Nuclear localisation of West Nile virus NS5 protein modulates host gene expression

In this study, we interrogated the potential nuclear functions of WNVKUN NS5 has on the host transcriptome, by means of RNA sequencing (RNAseq). In a direct comparison between wild type and mutant NS5, it can also be determined that the nuclear translocation of NS5 results in a significant down-regulation of host genes involved in the innate immune response. When compared to published RNAseq data from WNV infection, many of these genes were overlapping indicting the role of NS5 induced transcription during infection.PMID:33866234 | DOI:10.1016/j.virol.2021.03.018

Source: Virology - April 18, 2021 Category: Virology Authors: Adam J L ópez-Denman Daniel E Tuipulotu Jessica B Ross Alice M Trenerry Peter A White Jason M Mackenzie Source Type: research