Scientists identify protein that could serve as a therapeutic target in lung cancer

(Virginia Commonwealth University) A new study led by scientists at VCU Massey Cancer Center suggests that gain-of-function mutations turn p53 into an oncogene, causing cells to replicate uncontrollably and contribute to cancer development. Recently published in Nature Communications, the researchers determined that mutant p53 genes are empowered by a specific protein, PLK3, to copy their genetic code and promote tumor cell proliferation through a process called transactivation.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news