New treatment for ED after prostate surgery being developed, researchers say

Men undergoing surgery for prostate cancer may no longer have to live with erectile dysfunction afterward, thanks to an innovative new treatment, researchers said in a paper published Monday by JCI Insight.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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AbstractPurposeAnalysis of quality of life changes after radiotherapy with focus on the impact of time after treatment and prescription dose.MethodsConsecutive patients were treated with doses from 70.2/1.8  Gy (n = 206) to 72/1.8–2.0 Gy (n = 176) in a single centre and surveyed using the Expanded Prostate Cancer Index Composite questionnaire.ResultsUrinary and bowel bother scores decreased 1 / 3 / 6 points and 7 / 7 / 9 points on average 1 / 5 / 10  years after RT in comparison to baseline scores. The rate of urinary (need of pads in 8% vs. 15% before vs. 10 years...
Source: Quality of Life Research - Category: Health Management Source Type: research
CONCLUSIONS: Urethral complications related to prostate RT are seldom an isolated problem and require a substantial amount of urological resources and interventions. PMID: 32701436 [PubMed - as supplied by publisher]
Source: Canadian Urological Association Journal - Category: Urology & Nephrology Authors: Tags: Can Urol Assoc J Source Type: research
CONCLUSIONS: UI and ED frequently occur in patients with localized and locally advanced CaP, in particular after radical prostatectomy. The higher occurrence rate of UI and ED, compared with clinical trial participants, supports the importance of real-world data, which can be used for local treatment recommendations and patient information, but also to evaluate effects of future initiatives, such as treatment centralization and research aimed at improving functional outcomes. PMID: 32680820 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
Prostate cancer (PCa) is the mostcommon non-cutaneous canceramong men in the United States [1]. For some men with non-aggressive PCa, active surveillance could be a viable option. Though survival rates are favorable for localized prostate cancer, treatment-related toxicity become important. The common treatment options for localized PCa include surgery, RT, androgen deprivation therapy (ADT), or a combination of the treatments, and all have associated treatment related toxicities [4 –5]. Approximately 50% of patients undergoing radiation therapy will develop RiED within 3 to 5 years after the completion of RT.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
In this study, we investigated whether RhoA/ROCK pathway inhibition by a specific inhibitor called Hydroxyfasudil (HF) can improve RiED in our well-established rat model. MATERIALS /METHODS: Male Sprague-Dawley rats were randomized to the following groups: sham-RT, HF-only, RT-only, and RT+HF. Rats were either exposed to a single dose of 25 Gy prostate-confined RT or a sham procedure. 10mg/kg HF or normal saline was injected intraperitoneally. Erectile function was evaluated by intracavernosal pressure (ICP) and mean arterial pressure (MAP) measurements at week 14 post-RT. Cavernous nerve (CN) injury was evaluated by ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
AbstractBackgroundWe evaluated clinical outcomes of region target focal therapy with high-intensity focused ultrasound (HIFU) for the localized prostate cancer (PCa) based on magnetic resonance imaging-based biopsy and systematic prostate biopsy for Asian.MethodsWe prospectively recruited patients with localized PCa, located their significant tumors using MRI-transrectal ultrasound (TRUS) elastic fusion image-guided transperineal prostate biopsy and 12-cores transperineal systematic biopsy, and focally treated these regions in which the tumors were located in the prostate using HIFU. Patients ’ functional and oncolog...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurposeThe aim of this study was to report on the safety (complications) and efficacy (oncological and functional outcomes) of robot-assisted radical prostatectomy (RARP), performed at our institution, in patients aged over 70.Patients and methodsReview of our prospectively collected database [Cancer Information Systems (CAISIS)] identified two hundred and fifteen (215) patients, aged  >  70, who underwent RARP for localized prostate cancer between July 2003 and August 2017. A propensity score-matched analysis, with multiple covariates, was performed to stratify the patients into Age ≤&th...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
By AMY E. KRAMBECK, MD With the exceptions of pediatrics and obstetrics/gynecology, women make up fewer than half of all medical specialists. Representation is lowest in orthopedics (8%), followed by my own specialty, urology (12%). I can testify that the numbers are changing in urology – women are up from just 8% in 2015, and the breakdown in our residency program here at Indiana University is now about 20% of the 5-year program. One reason for the increase is likely the growth of women in medicine – 60% of doctors under 35 are women, as are more than half of medical school enrollees. I also credit a...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Physicians Amy Krambeck female physicians majority male specialties Patients Source Type: blogs
PROSTATE cancer symptoms can be difficult to spot during its early stages, but include passing more urine than normal, erectile dysfunction, and having a burning pain when using the loo. The speed of your urine flow may also reveal your risk of the disease. These are the warning signs of prostate cancer in the toilet.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Based on long-term follow-up, RP compared with WW probably results in substantially improved oncological outcomes in men with localised prostate cancer but also markedly increases rates of urinary incontinence and erectile dysfunction. These findings are largely based on men diagnosed before widespread PSA screening, thereby limiting generalisability. Compared to AM, based on follow-up to 10 years, RP probably has similar outcomes with regard to overall and disease-specific survival yet probably reduces the risks of disease progression and metastatic disease. Urinary function and sexual function are proba...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
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