Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis

Obesity often leads to nonalcoholic fatty liver disease (NAFLD), which can progress from simple steatosis (nonalcoholic fatty liver (NAFL)) to nonalcoholic steatohepatitis (NASH). The accumulation of certain lipid subtypes is linked with worsening metabolic and liver disease, however, specific changes during progression from No-NAFL to NAFL then NASH are unresolved. Here, we characterise the liver, adipose tissue and plasma lipidome of worsening NAFLD in obesity, and evaluate the utility of plasma lipids as biomarkers of NAFLD.

Source: Journal of Hepatology - April 19, 2021 Category: Gastroenterology Authors: Geraldine J. Ooi, Peter J. Meikle, Kevin Huynh, Arul Earnest, Stuart K. Roberts, William Kemp, Benjamin L. Parker, Wendy Brown, Paul Burton, Matthew J. Watt Source Type: research