181 Tristetraprolin family members repress early T cell cytokine production and are recurrently downregulated in diverse human rashes

Human inflammation activates dynamically, but the mechanisms underlying such sensitive kinetics remain incompletely understood. We single-cell profiled transcriptomes and epitopes from 24 diverse rashes in adults, including psoriasis, atopic dermatitis, lichen planus, and bullous pemphigoid. The tristetraprolin family members ZFP36 and ZFP36L2 were identified as recurrently, highly repressed transcripts in T cells (logeFC = -0.47 and -0.85 respectively; adjPvals

Source: Journal of Investigative Dermatology - April 19, 2021 Category: Dermatology Authors: C.P. Cook, Y. Liu, R. Schmidt, S.B. Ramos, A. Marson, R. Cho, J.B. Cheng Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research