Modified RANO (mRANO), iRANO, and standard RANO response to convection-enhanced delivery of IL4R-targeted immunotoxin MDNA55 in recurrent glioblastoma

CONCLUSIONS: No correlation between radiographic PFS and OS was observed for standard RANO or iRANO, but a correlation was observed between PFS and OS using the mRANO criteria. Also, the iRANO criteria was difficult to implement due to need to confirm progression 3 months after initial progression, censoring more than half the patients.PMID:33863808 | DOI:10.1158/1078-0432.CCR-21-0446

Source: Clinical Cancer Research - April 17, 2021 Category: Cancer & Oncology Authors: Benjamin M Ellingson John H Sampson Achal Singh Achrol Manish K Aghi Krystof Krystof Bankiewicz Chencai Wang Martin Bexon Steven Brem Andrew J Brenner Sajeel Chowdhary John R Floyd Seunggu Jude Han Santosh Kesari Dina Randazzo Michael A Vogelbaum Frank D Source Type: research