Development of a common peroneal nerve injury model in domestic swine for the study of translational neuropathic pain treatments

CONCLUSIONS: In a neuropathic pain model in domestic swine, the authors demonstrated that CPNI induces demyelination of the common peroneal nerve, which the authors hypothesize is responsible for the resulting allodynic pain behavior. As the anatomical features of domestic swine resemble those of humans more closely than previously used rat and mouse models, utilizing this swine model, which is to the authors' knowledge the first of its kind, will aid in the translation of experimental treatments to clinical trials.PMID:33862596 | DOI:10.3171/2020.9.JNS202961

Source: Journal of Neurosurgery - April 16, 2021 Category: Neurosurgery Authors: Abigail Hellman Teresa Maietta Alicia Clum Kanakaharini Byraju Nataly Raviv Michael D Staudt Erin Jeannotte Julia Nalwalk Sophie Belin Yannick Poitelon Julie G Pilitsis Source Type: research