Deficiency in Nebulin Repeats of Sarcomeric Nebulette is Detrimental for Cardiomyocyte Tolerance to Exercise and Biomechanical Stress

CONCLUSIONS: Upon stretch, NEBL deficiency causes disturbed sarcomere, Z-disks and desmin organization, and prevents NEBL redistribution to focal adhesions in cardiomyocytes, weakening cardiac tolerance to stress.PMID:33861145 | DOI:10.1152/ajpheart.00732.2020

Source: American Journal of Physiology. Heart and Circulatory Physiology - April 16, 2021 Category: Physiology Authors: Ramona M Vejandla Buyan-Ochir Orgil Neely R Alberson Ning Li Undral Munkhsaikhan Zaza Khuchua Ruben Martherus Evren U Azeloglu Fuyi Xu Lu Lu Jeffrey A Towbin Enkhsaikhan Purevjav Source Type: research