Cancers, Vol. 13, Pages 1944: Graves ’ Disease During Immune Checkpoint Inhibitor Therapy (A Case Series and Literature Review)

In conclusion, GD is a rare, immune-related adverse event of ICPis with an unusual course and frequent evolution to biphasic thyroiditis. In the case of ICPi-induced thyrotoxicosis in the presence of TRAb, observing the spontaneous evolution and performing a scintigraphy are useful before starting ATD treatment. Pre-existing GD is not exacerbated by ICPis and tends to evolve towards hypothyroidism. ICPi treatment can be maintained with adequate biochemical surveillance.

Source: Cancers - April 17, 2021 Category: Cancer & Oncology Authors: Mathilde Peiffert Christine Cugnet-Anceau Stephane Dalle Karim Chikh Souad Assaad Emmanuel Disse G érald Raverot Fran çoise Borson-Chazot Juliette Abeillon-du Payrat Tags: Article Source Type: research