Naoxintong capsules modulates tumor necrosis factor--induced endothelial senescence through silent information regulator 1 signaling
CONCLUSIONS: These findings suggest that sustained endothelial senescence can be induced by TNF-α stimulation via the SIRT1/FoxO-1/p53/p21 pathway. The protection of NXT against TNF- was partially mediated through its effects on SIRT1. This highlights the promise of NXT as a therapeutic for atherosclerosis.PMID:33825400
Source: Journal of Traditional Chinese Medicine - Category: Complementary Medicine Authors: Qianyun Guo Bin Zhang Haitong Zhang Erli Zhang Yongjian Wu Source Type: research
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