CAR T cells Targeting Human Immunoglobulin Light Chains Eradicate Mature B Cell Malignancies While Sparing a Subset of Normal B Cells

CONCLUSIONS: Adoptive transfer of CAR.λ and CAR.κ-T cells represents a useful and alternative modality to CAR.CD19-T cells in treating mature B-cell malignancies with minimal impact on humoral immunity.PMID:33858858 | DOI:10.1158/1078-0432.CCR-20-2754

Source: Clinical Cancer Research - April 16, 2021 Category: Cancer & Oncology Authors: Raghuveer Ranganathan Peishun Shou Sarah Ahn Chuang Sun John West Barbara Savoldo Gianpietro Dotti Source Type: research