Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis

J Immunol Res. 2021 Mar 29;2021:6657785. doi: 10.1155/2021/6657785. eCollection 2021.ABSTRACTBACKGROUND: Cytokines and growth factors involved in the tissue inflammatory process influence the outcome of Leishmania infection. Insulin-like growth factor (IGF-I) constitutively present in the skin may participate in the inflammatory process and parasite-host interaction. Previous work has shown that preincubation of Leishmania (Leishmania) amazonensis with recombinant IGF-I induces accelerated lesion development. However, in human cutaneous leishmaniasis (CL) pathogenesis, it is more relevant to the persistent inflammatory process than progressive parasite proliferation. In this context, we aimed to investigate whether IGF-I was present in the CL lesions and if this factor may influence the lesions' development acting on parasite growth and/or on the inflammatory/healing process. Methodology. Fifty-one CL patients' skin lesion samples from endemic area of L. (Viannia) braziliensis infection were submitted to histopathological analysis and searched for Leishmania and IGF-I expression by immunohistochemistry.RESULTS: In human CL lesions, IGF-I was observed preferentially in the late lesion (more than 90 days), and the percentage of positive area for IGF-I was positively correlated with duration of illness (r = 0.42, P
Source: Journal of Immunology Research - Category: Allergy & Immunology Authors: Source Type: research

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Parasitol Res. 2021 Oct 19. doi: 10.1007/s00436-021-07342-1. Online ahead of print.ABSTRACTVisceral leishmaniasis (VL) is a neglected tropical disease of global importance caused by parasites of the genus Leishmania, and coinfection with human immunodeficiency virus (HIV) is common in countries where both diseases are endemic. In particular, widely used immunological tests for VL diagnosis have impaired sensitivity (Se) and specificity (Sp) in VL/HIV coinfected patients and there is also cross-reactivity with other endemic diseases, e.g., Chagas disease, malaria, and tuberculosis. To develop new antigens to improve the dia...
Source: Cell Research - Category: Cytology Authors: Source Type: research
Biomed Res Int. 2021 Oct 5;2021:3192960. doi: 10.1155/2021/3192960. eCollection 2021.ABSTRACTDogs are the main reservoir of Leishmania infantum in endemic regions. Canine leishmaniasis, caused by L. infantum, can progress to a chronic disease resulting in death. Vaccines have been developed with a certain degree of success. The pathogenesis of this disease is not completely understood, especially in previously vaccinated dogs. We herein described clinical data, parasite load, serum levels of cytokines, and the reservoir potential in vdogs vaccinated with the fucose-mannose ligand (FML)/QuilA saponin vaccine (Leishmune&trad...
Source: Biomed Res - Category: Research Authors: Source Type: research
Leishmaniasis is endemic to the tropical and subtropical regions of the world and is transmitted by the bite of an infected sand fly. The multifaceted interactions between Leishmania, the host innate immune cells, and the adaptive immunity determine the severity of pathogenesis and disease development. Leishmania parasites establish a chronic infection by subversion and attenuation of the microbicidal functions of phagocytic innate immune cells such as neutrophils, macrophages and dendritic cells (DCs). Other innate cells such as inflammatory monocytes, mast cells and NK cells, also contribute to resistance and/or suscepti...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Many laboratory methods are used to diagnose leishmaniasis because it is characterized by varied symptoms and caused by different Leishmania species. A quantitative real-time PCR method based on a TaqMan probe was developed and modified for accurate identification of human cutaneous leishmaniasis (caused by Leishmania major or Leishmania tropica) from endemic areas of Iran. Two gene regions of amino acid permease 3 (AAP3) and cytochrome oxidase II (COII) were considered. Six new sets of species-specific primers and probes were designed. A total of 123 samples were examined and employed to evaluate and validate real-time PC...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
AbstractLeishmaniasis is a disease that represents a serious global health problem with a potentially fatal outcome in some cases.Leishmaniaspp. is transmitted by the bite of a sandfly and the disease is endemic in 98 countries. Treatment is carried out with toxic drugs and not consistently effective, so there is a need for new treatments. Oxadiazoles are five-membered heterocyclic compounds, and their antileishmanial activity is well documented in the literature. Specifically,n-cyclohexyl-1,2,4-oxadiazole (2b) was designed to obtain the simplified molecular data line entry system (SMILES). The approach for predicting phar...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
Leishmania parasites, endemic in (sub-)tropical regions, cause a neglected tropical disease affecting ∼12 million cases worldwide. The spectrum of pathologies ranges from cutaneous leishmaniasis to progressive fatal visceral disease. Both in humans and mice, healing is associated with successful development of IFNγ-producing Th1/Tc1 cells, whereas Th2-, Th17- and Treg-predominant responses are as sociated with progression and/or non-healing lesions (Sacks&Noben-Trauth, 2002; Kautz-Neu et al., 2011).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
Leishmania parasites, endemic in (sub)tropical regions, cause a neglected tropical disease affecting ∼12 million cases worldwide. The spectrum of pathologies ranges from cutaneous leishmaniasis to progressive fatal visceral disease. Both in humans and mice, healing is associated with successful development of IFN-γ‒producing T helper type (Th)1/Tc1 cells, whereas Th2-, Th17-, and regulatory T- cell‒predominant responses are associated with progression and/or nonhealing lesions (Kautz-Neu et al., 2011; Sacks and Noben-Trauth, 2002).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
We describe a case of a 61-year-old woman who presented with an asymptomatic red-brown papule on her lower back approximately one year after returning to the United States from a trip to Ethiopia and Cameroon. Polymerase chain reaction was performed on the biopsy material and identified Leishmania aethiopica. This case highlights an atypical location and demonstrates how to accurately diagnose and treat this parasitic infection.
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
Rev Argent Microbiol. 2021 Sep 6:S0325-7541(21)00077-8. doi: 10.1016/j.ram.2021.06.002. Online ahead of print.ABSTRACTTegumentary leishmaniasis (TL) is caused by parasites of the genus Leishmania and transmitted by the sandfly species, insects belonging to the order Diptera, family Psychodidae. Historically, the most endemic area of TL in Argentina has been the northern region. The aim of this work was to analyze the presence and temporal variation of TL cases reported between 1985 and 2019 in Colonia Santa Rosa locality, northern Argentina. Furthermore, its clinical forms were characterized and sandflies were captured. Pa...
Source: Revista Argentina de Microbiologia - Category: Microbiology Authors: Source Type: research
Leishmania tarentolae is a protozoan isolated from geckoes (Tarentola annularis, Tarentola mauritanica), which is considered non-pathogenic and is transmitted by herpetophilic Sergentomyia spp. sand flies. This s...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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