Novel MET Exon 14 Skipping Analogs Characterized in Non-Small Cell Lung Cancer Patients: A Case Study

The MET gene, located at chromosome 7q21-q31, encodes the widely expressed receptor of hepatocyte growth factor (HGF), which is involved in various cellular processes, including cell growth, proliferation, survival, migration, and differentiation [1]. Gain-of-function alteration in MET is known as a primary oncogenic driver and a major factor for resistance to tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) treatment [2-4].
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research