Macrophage Activation Syndrome in Children: Diagnosis and Management

Indian Pediatr. 2021 Mar 26:S097475591600308. Online ahead of print.ABSTRACTMacrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome.PMID:33772536
Source: Indian Pediatrics - Category: Pediatrics Authors: Source Type: research