MicroRNA-223 Suppresses IL-1 β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome

Conclusion: These findings suggest that miR-223 provides negative feedback regulation of the development of gouty inflammation by suppressing production of IL-1β and TNF-α, but not by regulating IL-37 and TGF-β1. Moreover, miR-223 regulates cytokine production by targeting the NLRP3 inflammasome.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research