Cancers, Vol. 13, Pages 1926: Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer

Cancers, Vol. 13, Pages 1926: Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer Cancers doi: 10.3390/cancers13081926 Authors: Lauren C. Cutmore John F. Marshall CAR T cells have revolutionised the treatment of haematological malignancies. Despite this, several obstacles still prohibit their widespread use and efficacy. One of these barriers is the use of autologous T cells as the carrier of the CAR. The individual production of CAR T cells results in large variation in the product, greater wait times for treatment and higher costs. To overcome this several novel approaches have emerged that utilise allogeneic cells, so called “off the shelf” CAR T cells. In this Review, we describe the different approaches that have been used to produce allogeneic CAR T to date, as well as their current pre-clinical and clinical progress.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research