Naoxintong capsules modulates tumor necrosis factor--induced endothelial senescence through silent information regulator 1 signaling

CONCLUSIONS: These findings suggest that sustained endothelial senescence can be induced by TNF-α stimulation via the SIRT1/FoxO-1/p53/p21 pathway. The protection of NXT against TNF- was partially mediated through its effects on SIRT1. This highlights the promise of NXT as a therapeutic for atherosclerosis.PMID:33825400
Source: Journal of Traditional Chinese Medicine - Category: Complementary Medicine Authors: Source Type: research