Vaccines Won ’t Protect Millions of Patients With Weakened Immune Systems

Many cannot produce enough infection-fighting cells to fend off the coronavirus. But researchers are testing one therapy that may help: monoclonal antibodies.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Antibodies Coronavirus (2019-nCoV) Vaccination and Immunization Immune System Drugs (Pharmaceuticals) Autoimmune Diseases Rituxan Leukemia & Lymphoma Society Regeneron Pharmaceuticals Inc Source Type: news

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Hopefully, we will someday be united again – if not on issues, at least on the facts, writes guest columnist Stan Silverman.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
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Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: SPECIAL COMMUNICATIONS: Letters to the Editor-in-Chief Source Type: research
In this study, we tested and validated a monoclonal antibody to IRF8 as a novel immunohistochemical stain for trephine core biopsies of human bone marrow. We assessed the expression of IRF8 in 90 cases of AMoL, including posttherapy staging bone marrows, 23 cases of chronic myelomonocytic leukemia, 26 cases of other acute myeloid leukemia subtypes, and 18 normal control marrows. In AMoL, there was high correlation of IRF8-positive cells to aspirate blast count (R=0.95). Comparison of IRF8 staining to aspirate blast percentage in chronic myelomonocytic leukemia also showed good correlation (R=0.86). In contrast, IRF8-positi...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
In this study, we investigated by immunohistochemical analysis the expression of E-cadherin (EC) on pDCs in reactive lymph nodes and tonsils, bone marrow, and in BPDCN. We compared the expression of EC in BPDCN to that in leukemia cutis (LC) and cutaneous lupus erythematosus (CLE), the latter typically featuring pDC activation. In BPDCN, we also assessed the immunomodulatory activity of malignant pDCs through the expression of several type I interferon (IFN-I) signaling effectors and downstream targets, PD-L1/CD274, and determined the extent of tumor infiltration by CD8-expressing T cells. In reactive lymph nodes and tonsi...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Although follicular lymphoma (FL) is usually graded as FL1-2, FL3A, and FL3B, some borderline cases can be observed and led us to investigate the clinicopathologic diversity of grade 3 FL (FL3). Among 2449 FL patients enrolled in Lymphoma Study Association (LYSA) trials, 1921 cases with sufficient material underwent a central pathologic review. The resulting diagnoses comprised 89.6% FL1-2 (n=1723), 7.2% FL3A (n=138), and 0.5% purely follicular FL3B (n=9). The remaining 51 unclassifiable cases (2.7%) exhibited high-grade features but did not meet WHO criteria for either FL3A or FL3B; and were considered as “unconvent...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
The Durham company is committing $100 million to advance a combination therapy aimed at treating Covid-19 following positive results from a trial sponsored by the National Institutes of Health.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
ConclusionsOur results show that the COVID-19 pandemic has impacted GI fellowship training in the USA in multiple domains, including gastrointestinal endoscopy, inpatient consults, outpatient clinics, and educational conferences. Our study highlights the importance of considering and incorporating fellows ’ viewpoints, as changes are made in response to the ongoing pandemic.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
DiscussionMusculoskeletal problems are common problems in pediatric practice with up to 15% of acute care visits being for this problem. Joint pain is a common concern for families but the differential diagnosis is extensive and needs thoughtful consideration. History is a key to discerning the potential diagnosis but also in guiding the physical examination and laboratory examination. Family history especially for systemic diseases should be considered. On physical examination all joints should be examined include sacroiliac and temporomandibular joints. Is this arthritis or arthralgia? Distinction between inflammatory...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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